Synthetic applications of chiral 1,3-dioxolan-4-ones and 3-acyloxazolidin-5-ones
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Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease
Seasonal and pandemic influenza outbreaks remain a major human health problem. Inhibition of the endonuclease activity of influenza RNA-dependent RNA polymerase is attractive for the development of new agents for the treatment of influenza infection. Our earlier studies identified a series of 5- and 6-phenyl substituted 3-hydroxypyridin-2(1H)-ones that were effective inhibitors of influenza end...
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4-Sulfenyl-2-carbamoyl-4-isoxazolin-3-ones (4) were designed on the basis of biological isosterism and prepared in four steps. Some of these compounds showed sufficient pre-emergent herbicidal activities against various kinds of weeds. Among the synthesized compounds, 2-(N-(4-chlorophenyl)-N-isopropylcarbamoyl)-4-ethylthio-5-methyl-4 -isoxazolin-3-one (4cd) exhibited the most promising activity.
متن کاملSOME UNUSUAL REACTIONS OF 3-PHENYLAMINOISOXAZOL-5 (2H)- ONES
3-Phenylaminoisoxazol-5(2H)-ones,s ubstituted on nitrogen with an isoquinoline or quinazoline group, react with tertiary amine bases to give imidazo annelated compounds. When the N-substituent is a nitropyridine, 2-aminoindole derivatives are formed instead. Evidence is presented that the reactions proceed by initial addition of the tertiary arnine to C-4
متن کاملAnalgesic activity of new synthetic thiazolidine-4-ones derivatives.
Ten new synthetic thiazolidine-4-ones derivatives (5 chlorothiazolidine-4-ones, 3 methoxythiazolidine-4-ones and 2 hydoxythiazolidine-4-ones) having different substituents at R1, R2 and R3 were evaluated for their analgesic activity using different animal models and their structure activity relationship was also elucidated. Chlorothiazolidine-4-ones and methoxythiazolidine-4-ones exhibited anal...
متن کاملRegioselective Lithiation of Chiral 3-Acylamino-2-alkylquinazolin-4(3H)-ones: Application in Synthesis
Template for SYNLETT and SYNTHESIS © Thieme Stuttgart · New York 2004-05-13 page 1 of 15 Abstract: Reaction of 3-amino-2-alkylquinazolin-4(3H)-ones with several chiral acid chlorides was found to be dependent on the molar proportions. When a 1:1 molar mixture was heated under reflux, the corresponding 3-(diacylamino)derivatives were obtained in poor yields. However, when a 2:1 molar mixture was...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2006
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0007.721